![]() I have a friend right now whose husband has ESLD. By contrast, he was transplanted within 5 months in NC with a MELD score of 24. By the next week after a week in ICU, his MELD score dropped into the high 20's and his hopes for transplant were dashed. Therefore, the most appropriate system to support patient selection for transplantation will be one that combines a pretransplant survival model (e.g., MELD score) with a properly developed post-transplant survival model. He was 1 on the list in the entire NYC metropolitan area and yet did not get a liver that week. These results are in agreement with results found in the United States. In conclusion, in the UK and Ireland the MELD score is significantly associated with post-transplant survival, but its predictive ability is poor. Re-estimating the coefficients in the MELD regression model, even allowing for nonlinear relationships, did not improve its discriminatory ability. As a consequence, the ability of the MELD score to discriminate between patients who were dead or alive was poor (c-statistic 0.58). The risk of death due to transplant is 15. A MELD of 15 indicates that a patient has liver disease, and the risk of transplant is equal to the risk of the liver disease itself. Any MELD above 6 is an indication of liver disease. A MELD score for a healthy person is under 5. Therefore, only those patients with a MELD score of 36 or higher (3% of the patients) had a survival that was markedly lower than the rest. The MELD score ranges from a low of 0 to a high of 40. The 90-day survival varied according to the United Network for Organ Sharing MELD categories (92.6%, 91.9%, 89.7%, 89.7%, and 70.8%, respectively P < 0.01). The overall survival at 90-days was 90.2%. We studied survival of 3838 adult patients after first elective liver transplantation according to United Network for Organ Sharing categories of their MELD scores ( or =36). The UK and Ireland Liver Transplant Audit has data on all liver transplants since 1994. Our aim was to evaluate how accurately the MELD score predicts 90-day post-transplant survival in adult patients with chronic liver disease in the UK and Ireland. Four recent studies carried out in the United States have demonstrated that the MELD score obtained immediately prior to transplantation is also associated with post-transplant patient survival. It has been shown that the model for end-stage liver disease (MELD) score is an accurate predictor of survival in patients with liver disease without transplantation. ![]()
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